Mesenchymal stem cell tracking in the intervertebral disc
نویسندگان
چکیده
منابع مشابه
Mesenchymal Stem Cell in the Intervertebral Disc
Degeneration of the intervertebral disc (IVD) is a major spinal disorder that causes back pain. Nucleus pulposus (NP) in the central of IVD dehydrates and become more fibrous in the IVD degeneration. NP cells undergo apoptosis with the degeneration of extracellular matrix (ECM) components. To replenish the NP cells and core ECM, bone marrow mesenchymal stromal cells (BMSCs) have been highlighte...
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Low back pain is one of the largest health problems in the Western world today, and intervertebral disc degeneration has been identified as a main cause. Currently, treatments are symptomatic, but cell-based tissue engineering methods are realistic alternatives for tissue regeneration. However, the major problem for these strategies is the generation of a suitable population of cells. Adult bon...
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Intervertebral disc degeneration remains a pervasive and intractable disease arising from a combination of aging and stress on the back and spine. The growing field of regenerative medicine brings the promise of stem cells in the treatment of disc disease. Scientists and physicians hope to employ stem cells not only to stop, but also reverse degeneration. However, there are many important outst...
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BACKGROUND Degenerative diseases are a medical, social, and economic problem worldwide. The most significant factors predisposing the development of degenerative changes in intervertebral discs are a low density and poor biosynthetic potential of the cells. Therefore, stem cell therapy in this case should show high clinical efficiency. METHODS The research aim was to evaluate the regenerative...
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Disc degeneration (DD) is a major musculoskeletal condition affecting 80% of the general global population [1]. The associated low back pain (LBP) has major socioeconomic impact reviewed in [2]. In the past 25 years a number of promising biological therapies have been investigated for the treatment of degenerative Disc Disease (DDD) and these have identified many potential molecular targets for...
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ژورنال
عنوان ژورنال: World Journal of Stem Cells
سال: 2015
ISSN: 1948-0210
DOI: 10.4252/wjsc.v7.i1.65